Publications

G. Fontés, B. Zarrouki, D. K. Hagman, M. G. Latour, M. Semache, V. Roskens, P. C. Moore, M. Prentki, C. J. Rhodes, T. L. Jetton, V. Poitout.
Glucolipotoxicity age-dependently impairs ß-cell function in rats despite a marked increase in ß-cell mass.
Diabetologia 2010, 53:2369-2379.

G. Fontes, G. K. Hagman, M. G. Latour, M. Semache, V. Poitout.
Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity.
Diabetes Research and Clinical Practice 2010, 87(3):322-8.

J. Lamontagne, E. Pepin, M-L. Peyot, E. Joly, N.B. Ruderman, V. Poitout, S.R.M. Madiraju, C.J. Nolan, M. Prentki.
Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic ß-cell at submaximal glucose concentrations.
Endocrinology 2009, 150(8):3465-74.

T. Alquier, M-L. Peyot, M. G. Latour, M. Kebede, C.M. Sorensen, S. Gesta, C.R. Kahn, R.D. Smith, T.L. Jetton, T.O. Metz, M. Prentki, V. Poitout.
Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.
Diabetes 2009, 58(11):2607-15.

M-L. Peyot, C. Guay, M.G. Latour, J. Lamontagne, R. Lussier, M. Pineda, N.B. Ruderman, G. Haemmerle, R. Zechner, E. Joly, S.R.M. Madiraju, V. Poitout, M. Prentki.
Adipose triglyceride lipase is implicated in fuel and non-fuel stimulated insulin secretion.
J. Biol Chem 2009, 284(25):16848-859.

G. Fontés, M. Semache, D. Hagman, C. Tremblay, R. Shah, C.J. Rhodes, J. Rutter, V. Poitout.
Involvement of PAS Kinase and ERK ½ in palmitate inhibition of insulin gene expression in pancreatic beta cells. 
Diabetes 2009, 58: 2048-2058.

M. Kebede, T. Alquier, M.G. Latour, M. Semache C. Tremblay, V. Poitout.
The fatty-acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.
Diabetes 2008, 57:2432-2437.

D.K. Hagman, M.G. Latour, S.K. Chakrabarti, G. Fontes, J. Amyot, C. Tremblay, M. Semache, J.A. Lausier, V. Roskens, R.G. Mirmira, T.L. Jetton, V. Poitout.
Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.
Diabetes 2008, 57:424-431.

M.G. Latour, T. Alquier, E. Oseid, C. Tremblay, T.L. Jetton, J. Luo, D.C.-H. Lin, V. Poitout.
GPR40 is necessary but not sufficient for fatty-acid stimulation of insulin secretion in vivo.
Diabetes 2007, 56:1087-1094.