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Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot ML, Ruderman NB, Nolan CJ, Joly E, Madiraju SR, Poitout V, Prentki M.
Pioglitazone acutely reduces energy metabolism and insulin secretion in rats.
Diabetes 2013 Feb 1. [Epub ahead of print]
Publications
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Ferdaoussi M, Bergeron V, Zarrouki B, Kolic J, Cantley J, Fielitz J, Olson EN, Prentki M, Biden T, MacDonald PE, Poitout V.
G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.
Diabetologia 2012, 55(10):2682-92.
G. Fontés, B. Zarrouki, D. K. Hagman, M. G. Latour, M. Semache, V. Roskens, P. C. Moore, M. Prentki, C. J. Rhodes, T. L. Jetton, V. Poitout.
Glucolipotoxicity age-dependently impairs ß-cell function in rats despite a marked increase in ß-cell mass.
Diabetologia 2010, 53:2369-2379.
J. Chen, F. Fontes, G. Saxena, V. Poitout, A. Shalev.
Lack of TXNIP protects against mitochondria-mediated apoptosis, but not against fatty acid-induced, ER-stress-mediated beta cell death.
Diabetes 2010, 59:440-447.
G. Fontes, G. K. Hagman, M. G. Latour, M. Semache, V. Poitout.
Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity.
Diabetes Research and Clinical Practice 2010, 87(3):322-8.
J. Lamontagne, E. Pepin, M-L. Peyot, E. Joly, N.B. Ruderman, V. Poitout, S.R.M. Madiraju, C.J. Nolan, M. Prentki.
Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic ß-cell at submaximal glucose concentrations.
Endocrinology 2009, 150(8):3465-74.
T. Alquier, M-L. Peyot, M. G. Latour, M. Kebede, C.M. Sorensen, S. Gesta, C.R. Kahn, R.D. Smith, T.L. Jetton, T.O. Metz, M. Prentki, V. Poitout.
Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets.
Diabetes 2009, 58(11):2607-15.
M-L. Peyot, C. Guay, M.G. Latour, J. Lamontagne, R. Lussier, M. Pineda, N.B. Ruderman, G. Haemmerle, R. Zechner, E. Joly, S.R.M. Madiraju, V. Poitout, M. Prentki.
Adipose triglyceride lipase is implicated in fuel and non-fuel stimulated insulin secretion.
J. Biol Chem 2009, 284(25):16848-859.
G. Fontés, M. Semache, D. Hagman, C. Tremblay, R. Shah, C.J. Rhodes, J. Rutter, V. Poitout.
Involvement of PAS Kinase and ERK ½ in palmitate inhibition of insulin gene expression in pancreatic beta cells.
Diabetes 2009, 58: 2048-2058.
M. Kebede, T. Alquier, M.G. Latour, M. Semache C. Tremblay, V. Poitout.
The fatty-acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.
Diabetes 2008, 57:2432-2437.
D.K. Hagman, M.G. Latour, S.K. Chakrabarti, G. Fontes, J. Amyot, C. Tremblay, M. Semache, J.A. Lausier, V. Roskens, R.G. Mirmira, T.L. Jetton, V. Poitout.
Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.
Diabetes 2008, 57:424-431.
M.G. Latour, T. Alquier, E. Oseid, C. Tremblay, T.L. Jetton, J. Luo, D.C.-H. Lin, V. Poitout.
GPR40 is necessary but not sufficient for fatty-acid stimulation of insulin secretion in vivo.
Diabetes 2007, 56:1087-1094.
